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pentobarbital will lower the extent or result of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Sturdy or reasonable CYP3A inducers may lessen cobimetinib systemic exposure by >eighty% and reduce its efficacy.pentobarbital will reduce the extent or impact of carbamazepine by i